Clinical trial of Δ1-testololactone (NSC 23759), medroxy progesterone acetate (NSC 26386) and oxylone acetate (NSC 47438) in advanced female mammary cancer:A report of the cooperative breast cancer group
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Covalent Binding of Elliptinium Acetate (NSC 264137) to Nucleic Acids of L1210 Cells in Culture1
I Ilipiiiiiiiin acétate(9-OH-NME; Celiptium) is an antineoplastic agent currently used in the treatment of metastatic breast cancer and is known to intercalate into DNA. Previous studies have demonstrated that this molecule can be oxidized, yielding a reactive electrophilic form, which is able to bind covalently to a nucleophilic biological molecule. In this work, we evidenced a covalent bindi...
متن کاملCovalent binding of elliptinium acetate (NSC 264137) to nucleic acids of L1210 cells in culture.
Elliptinium acetate (9-OH-NME; Celiptium) is an antineoplastic agent currently used in the treatment of metastatic breast cancer and is known to intercalate into DNA. Previous studies have demonstrated that this molecule can be oxidized, yielding a reactive electrophilic form, which is able to bind covalently to a nucleophilic biological molecule. In this work, we evidenced a covalent binding o...
متن کاملPhase I trial of temozolomide (NSC 362856) in patients with advanced cancer.
Temozolomide (TMZ) is a new imidazotetrazine derivative with early clinical activity in glioma and melanoma. The purpose of this Phase I study is to characterize the toxicity, pharmacokinetics, and antitumor activity of TMZ administered on an oral 5-day schedule to patients with or without prior exposure to nitrosourea (NU). Thirty-six eligible patients received a total of 77 cycles of therapy ...
متن کاملClinical Investigation of the Physiologic Disposition of a Phthalanilide (nsc-38280) and a Phthalamidine Derivative (nsc-57155) in 7 Patients.
thalanilides (10) in animals (2—7, 9, 13, 15, 20, 21, 24, 28— 31, 33, 34) and tissue culture (12, 23, 32),@clinical trial of these compounds has been described by various investi gators (16—18,22). This report deals with the absorption and excretion of the radioactivity of C'4-labeled 4' ,4―bis(2-imidazolin-2-yl) 2-chloroterephthalanilide dihydro chloride (NSC-38280)4 after P.O. and I.V...
متن کاملCancer Therapy: Clinical Phase I Trial of Bortezomib (PS-341; NSC 681239) and Alvocidib (Flavopiridol; NSC 649890) in Patients with Recurrent or Refractory B-Cell Neoplasms
Purpose: A phase I study was conducted to determine the dose-limiting toxicities (DLT) and maximum tolerated dose (MTD) for the combination of bortezomib and alvocidib in patients with B-cell malignancies (multiple myeloma, indolent lymphoma, and mantle cell lymphoma). Experimental Design: Patients received bortezomib by intravenous push on days 1, 4, 8, and 11. Patients also received alvocidib...
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ژورنال
عنوان ژورنال: Cancer
سال: 1969
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(196901)23:1<109::aid-cncr2820230112>3.0.co;2-1